In 2025, the Joint Programme’s support in the Latin America and the Caribbean region resulted in significant progress in HIV services, community-led response and systems strengthening. The Joint Programme advanced evidence-based prevention approaches including pre-exposure prophylaxis (PrEP), comprehensive sexuality education (CSE) and youth-friendly sexual and reproductive health (SRH) services while mobilizing regional coordination structures and strengthening policy environments. Community leadership, gender equality, human rights protection and municipal-level governance for the HIV response were expanded. At the same time, validation and certification processes for the elimination of vertical transmission of HIV along with new sustainability and financing mechanisms were also advanced. These results reflect a year of expanded partnerships, technical support, and community mobilization across more than 25 countries.
Latin America and the Caribbean
HIV prevention accelerated through the development and roll out of the PrEP IMPACT tool, to support national scale-up of oral PrEP. Seven countries began implementing PrEP while 1200 transgender women were reached through the PrEP Without Borders initiative across four countries. A regional Advanced HIV Disease study involving over 500 people across 11 countries prompted renewed attention to opportunistic infection management among people living with HIV. Progress on the elimination of vertical transmission of HIV was marked by Brazil’s formal validation by WHO and the adoption of national elimination roadmaps in four countries.
A reduction in adolescent risk behaviour was linked to a specific Joint Programme supported programme. Furthermore, adolescent SRH counseling guidelines strengthened inclusive, rights-based approaches, while youth-focused SRH initiatives built the capacity of 75 professionals across three countries.
Through the Being LGBTI in the Caribbean regional project, 199 transgender and gender-diverse persons received support to undergo psychological and socio-economic assessments and subsequently received tailored support to improve employability and economic integration. HIV related human rights and gender equality were prioritized by the Joint Programme. For instance, in one country 60 survivors of gender-based violence accessed legal services, while 30 public officials were engaged to improve survivor-centered services. Community-led action also expanded through evidence generation, including the completion of Stigma Index 2.0, and related multi-country analyses, informing advocacy. Furthermore, in one country, the Joint Programme provided technical support and tools for the development of a multi-agency platform which strengthened community-led advocacy on breastfeeding rights for women living with HIV, while HIV networks expanded to 61 municipalities with new digital tools for prevention policy.
With the sustainability of the HIV response being a critical priority, the Joint Programme and partners convened Ministers of Health from eight countries to advance governance reforms and domestic resource mobilization. This resulted in the finalization and approval of a harmonized tool that consolidates existing methods to strengthen data collection, analysis, and planning in support of a sustained HIV response across the region. Together, these efforts strengthened the foundations for a more resilient, domestically financed and community-informed HIV response across Latin America and the Caribbean.

